The Knack lead singer Doug Fieger wrote the lyrics to this song, which is about a girl he fancied. Doug was in a long-term relationship when he walked into the clothing store where a high school student named Sharona Alperin (who had a boyfriend), was working. The age difference (he was about 8 years older) and relationship status didn't deter Fieger, who was immediately lovestruck. With his girlfriend looking on, he invited Sharona to a show. Not long after, he broke up with the girlfriend and professed his love for Sharona, creating a weird dynamic where he would come on to her even though she had a boyfriend who often attended Knack concerts with her. It got pretty heavy when Fieger started writing songs about her - they weren't together when he composed "My Sharona."

About a year after they first met, Sharona gave in and they started dating. She joined the band on tour and watched as the song Fieger wrote about her elevated them to stardom. The couple were together for about four years (and engaged at one point) before the Rock and Roll lifestyle and Fieger's alcoholism became too much for Sharona, and they called it off. In the aftermath, Sharona answered questions about the breakup by saying that she needed to become her own Sharona, not someone else's.

After a cooling off period, Alperin and Fieger became friends. Alperin was with Fieger the last week of his life; he died of cancer on February 14, 2010.