Released in 1976, the album reached number one on the Billboard 200 the week ending April 10, 1976, and was in the top spot for a total of 10 weeks. It was the best-selling album of 1976, selling over 6 million copies in the US and became one of the best-selling live albums to date. Frampton Comes Alive! was voted "Album of the year" in the 1976 Rolling Stone readers poll. It stayed on the chart for 97 weeks.

The most recognizable songs from the album are Show me The Way, Baby, I Love Your Way, and Do You Feel Like We Do, all of which were released as singles, and continue to receive much airplay on radio stations.